Multimember transduction groups with sequential 5′ transductions involving splicing of 5′-transduced RNA sequences. Transduction groups with primary transduction events followed by secondary transductions of spliced host RNAs (A,B) and those with primary transductions of spliced host RNA sequences (C–E) are shown. Splice acceptor sites can be localized either within the SVA 5′ flanking intronic sequence, within primary transductions, or within the SVA Alu-like region. Exons and introns are not drawn to scale. Yellow boxes, primary transductions; green and pink boxes, secondary transductions; E1, exon 1; I1, intron 1; dotted green box, intronic sequence included in 5′ transduction; red ovals, TSDs; blue ovals, TSD sequence of the source element present in the 5′-transducing SVA; TD, transduction.
