Figure 7.
SVA alternative splicing outcomes. An intronic truncated SVA is shown (middle). The SVA is truncated because these SVAs are still likely to be spliced. If SVAs are exonized, they will likely generate a truncated protein or subject the mRNA to nonsense-mediated decay due to the inclusion of SVA nonsense codons (top). If SVAs mimic an endogenous gene-trap, that is provide a 3′ SS followed by termination at the SVA or downstream polyA signal, this may result in truncated proteins, but more importantly the retrotransposition of exons.
