BayesCall: A model-based base-calling algorithm for high-throughput short-read sequencing

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Table 4.

Gain in accuracy from different levels of modeling extra residual effects

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Table 4.
  • In BayesCall, extra residual effects are captured by the parameter αt. We used cycle-dependent parameters dt, σt2, Xt, and Σt in all three cases of BayesCall. Even without modeling extra residual effects (i.e., with αt = 0 for all t), BayesCall achieved an improvement of 38% over Bustard in the by-base error rate. When the full model with cycle-dependent αt was used, the improvement over Bustard increased to 55%.

This Article

  1. Genome Res. 19: 1884-1895

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