Direct multiplex sequencing (DMPS)—a novel method for targeted high-throughput sequencing of ancient and highly degraded DNA

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 4.
Figure 4.

DMPS applied to different samples and targets. Coverage plots resulting from a single round of amplification and sequencing are shown for mitochondrial or nuclear targets of cave bear, mammoth, polar bear, and African elephant. Only two example plots are shown for cave bears (with high and low target coverage), each representing the sequences obtained from two multiplex PCRs (odd and even).

This Article

  1. Genome Res. 19: 1843-1848

Preprint Server