Figure 4.
miRNA promoters have chromatin modification patterns similar to that of protein-coding genes. Chromatin modification patterns in the region surrounding the intergenic MIRLET7 miRNA cluster (A), and intragenic MIR98 and MIRLET7F2 (B), and MIR491 (C) are shown. Putative promoters are marked by H3K4me3, H2A.Z, and Pol II peaks. The green bars extend from the predicted transcription start site to the 3′ end of the pre-miRNA. H3K27me1, H3K9me1, H3K79me2, and H3K36me3 modifications, typically found within gene bodies of protein-coding genes, are seen within the putative miRNA coding transcript.
