Figure 3.
Inducible genes are poised for expression. (A–C) A majority of inducible genes have H3K4me3 (A), H2A.Z (B), and Pol II (C) at their promoters. The percentage of genes that have significant (P-value < 10−3) number of tags at the promoter for each set of genes is shown in resting (top panel) and activated (bottom panel) T cells. (D,E) Silent genes associated with cell cycle and metabolism, but not muscle or organ function and development, are poised in T cells. H3K4me3 (D) and Pol II (E) tag density profiles for silent genes taking part in specific biological processes.
