Figure 5.
Nucleosomes are strongly positioned at the CTCF-binding sites and the positioning is cell-type-specific. (A) Nucleosomes at the CTCF-binding sites in CD4+ T cells are phased. CTCF binds to the linker region surrounded by well-positioned nucleosomes. The deduced nucleosomes are indicated as ovals. (BS) CTCF-binding site. (B) Nucleosome positions in CD4+ T cells at the HeLa cell-specific CTCF-binding sites. A nucleosome occludes the CTCF-binding site where no binding is detected in CD4+ T cells. The possible nucleosome positions on the CTCF-binding site are indicated as ovals.
