Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains

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Figure 1.
Figure 1.

CTCF-binding sites overlap among different cell types. (A) Genome-wide distribution of CTCF-binding sites in CD4+ T cells, Jurkat cells, and HeLa cells. (B) CTCF-binding sites in CD4+ T cells, HeLa cells, and Jurkat cells overlap extensively. (C) Overlap of CTCF-binding sites in CD4+ T cells, HeLa cells, and Jurkat cells in an 850-kb region in chromosome 1, shown as custom tracks on the UCSC genome browser (Karolchik et al. 2008). (D) The densities of genes and CTCF-binding sites per 2 Mbp in chromosome 1. X-axis, number of genes/2 Mbp; y-axis, number of CTCF-binding sites/2 Mbp. (E) CTCF-binding motif in CD4+ T cells, HeLa cells, and Jurkat cells.

This Article

  1. Published in Advance December 3, 2008, doi: 10.1101/gr.082800.108 Genome Res. 19: 24-32

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