Figure 3.
mtDNA variations affect susceptibility to EAE. (A) Development of EAE in five conplastic strains. The x-axis presents the days post-immunization, and the y-axis indicates the EAE score. (B) Comparison of EAE clinical phenotypes, including disease incidence, onset day (only the disease mice were included), maximal disease score, and area under the curve (AUC). The C57BL/6J-mtAKR/J strain was taken as the reference strain, and the statistical significance was calculated for each strain compared with the C57BL/6J-mtAKR/J strain. Asterisks indicate significant differences: *P < 0.05; **P < 0.01; ***P < 0.001.
