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Cover Selected vertebrate animals with complete genome sequences are shown as a collage of seeds. In this issue, 23 vertebrate genomes are compared in order to identify and quantify conserved microRNA targeting, which is mediated by matches to “seed” regions at the 5′ ends of microRNAs. In all, 60% of genes are conserved targets of broadly-conserved vertebrate microRNAs. (Illustration by Robin Friedman and Shannon McArdel. [For details, see Friedman et al., pp. 92–105.])
