Inferring causal relationships of H3K27 trimethylation and binding of polycomb complexes. (A) Venn diagram visualizing the targeting genes shared by double, triple, or quadruple combinations among SUZ12, EED, RNF2, and H3K27me3. (B) Bayesian network inferred among the four factors. A directed edge denotes the occurrence of the target node is dependent on that of the source node, or that the occurrence of the source node is predictive of the target node. The probability distributions giving rise to the dependency for each node are given next to the node. For example, the conditional probability of RNF2 binding given the occurrence of H3K27me3, EED, and/or SUZ12 is listed below the RNF2 node.
