Confounding between recombination and selection, and the Ped/Pop method for detecting selection

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 2.
Figure 2.

Boxplots summarizing the distribution of LDhat recombination rate estimates from 100 chromosomes sequenced in 100-kb regions, simulated using SelSim to have at the center a positively selected variant with (unscaled) selection coefficient s. The pairwise algorithm of LDhat was used; 250 regions were simulated for each value of s; the effective population size was 104 diploid individuals; and the scaled recombination and mutation rates in each region were Rho = 50 and Theta = 100. The individual estimates underlying the s = 0 and s = 0.1 boxplots are displayed in Supplemental Figure S1.

This Article

  1. Genome Res. 18: 1304-1313

Preprint Server