A gene duplication affecting expression of the ovine ASIP gene is responsible for white and black sheep

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Figure 1.
Figure 1.

Schematic of the structure of the ovine ASIP gene showing the sizes of the three coding exons (black) and the intervening intron sequences (white). The exon–intron organization of the ovine gene is similar to that reported for the bovine, human, and mouse genes. Coding exons 2, 3, and 4 are separated by 1312- and 3481-bp intron sequences, respectively. The nucleotide positions of various described recessive black “non-agouti” mutations for the mouse, rat, horse, cat, fox, and dog are shown. The positions of four mutations identified from sheep in this study are shown.

This Article

  1. Genome Res. 18: 1282-1293

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