A genomic analysis of RNA polymerase II modification and chromatin architecture related to 3′ end RNA polyadenylation

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Figure 8.
Figure 8.

An example of another type of deviation from the standard pattern. In several large genes, such as SERPINB8, there are stretches of histone lysine 36 (K36) dimethylation extending over tens of kilobases and alternating with stretches of trimethylation. In some other genes, the pattern is revered with the 5′ end portion showing trimethylation. The functional significance of these patterns remains to be determined.

This Article

  1. Published in Advance May 16, 2008, doi: 10.1101/gr.075804.107 Genome Res. 18: 1224-1237

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