Example of another type of deviation from the standard pattern. In this figure, the dimethylation of both histone 3 lysine 36 (K36) and lysine 4 (K4) extends across the entire gene. Interestingly, histone dimethyl lysine 36 is also enriched for some distance upstream of the 5′ end of the CTGF gene and then decreased to lower levels over most of the body of the gene. Histone dimethyl lysine 4 shows almost the inverse pattern of dimethyl lysine 36, increasing later than lysine 36, mainly retained over the body of the gene, and dropping just before the 3′ end signal appears. It seems that PolII (4H8) and acetylated histone 4 were similarly distributed to histone dimethyl lysine 36 throughout this whole region. Unlike typical genes, trimethylations at lysine 4 and lysine 36 sites were essentially absent. Note that transcription of this gene proceeds right to left.
