Transcription induces strand-specific mutations at the 5′ end of human genes

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Figure 3.
Figure 3.

Ratios between complementary transition rates and the GC content plotted against distance from the 5′ end of genes calculated in 200-bp-long windows along the nontemplate strand, combined with information from all genes and presented by six different genomic contexts. (Intronic) Genes that were used in Figure 2; (introns w/o 200bp) the 200 bp in introns’ edges were excluded; (GC-rich windows and AT-rich windows) DNA sequences with GC content of >50% and <41%, respectively. Windows that contained less than 100 kbp-long DNA sequences were omitted (see Supplemental Fig. S15 for the amount of sequence in each window).

This Article

  1. Genome Res. 18: 1216-1223

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