
The ME tree of the TIR domain of insect TLRs, 48 amphioxus TLRs and vertebrate TLRs. The gene ID in gray represents alleles. The vertebrate TLR3, TLR5, and TLR7 families are too diverged to include in this tree. (Dashed lines) The possible position of those divergent sequences not used in the tree construction; (dots) the truncated P-TLRs. Another tree of more reliable statistical significance is shown in Supplemental Figure S3. (m) Mouse; (f) Fugu; (tet) tetraodon; (ch) chicken; (xt) Xenopus; (hal) halibut; (md) Musca domestica; (ag) Anopheles gambiae; (d) Drosophila.











