Direct targets of the TRP63 transcription factor revealed by a combination of gene expression profiling and reverse engineering

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 3.
Figure 3.

TSNI enriches for TRP63 direct targets. Average TRP63 binding score (BS) of genes associated to the top 100 TSNI-ranked transcripts and to the bottom 200 TSNI ranked transcripts (from rank 587 to rank 786) included on the array as controls. FC is the average BS obtained by ranking genes according to their fold changes following TRP63 induction; Early_genes is obtained by ranking genes according to their time of change upon ΔNp63α activation. siRNA is obtained by ranking genes according to their differential expression following Trp63 knockdown. (Dashed line) Central value of BS for a random selection of 100 genes. Significance is computed as compared with the average BS of a set of 100 transcripts picked at random. *P = 0.02.

This Article

  1. Published in Advance April 25, 2008, doi: 10.1101/gr.073601.107 Genome Res. 18: 939-948

Preprint Server



Current Issue

  1. February 2026, 36 (2)
  1. Current Issue
  1. Alert me to new issues of Genome Research