Figure 3.
Distribution of positions of hypomethylated sites in promoter, 1st exon, 1st intron, inner region of gene, and region containing no transcribed sequences: (A) MCF7, (B) MDA-MB-231, (C) tumor breast, (D) normal breast, and (E) normal brain. The extensively hypomethylated sites in MCF7 and MDA-MB-231 genomes are enriched in the intragenic and intergenic regions (P < 0.01, Fisher’s exact test). By contrast, normal tissue genomes are enriched in the promoter, exon 1, and intron 1 close to the 5′ end of the gene (P < 0.01, Fisher’s exact test).
