Co-expression modules enriched with cell cycle regulation accurately predict diabetes and obesity. Expression heat maps (A) and the PC1 on log10 scale (B) of the cell cycle regulatory modules in islets (217 transcripts) and adipose (96 transcripts) are shown. For the heat maps, red shows increased expression, green shows decreased expression, and black is neutral. Bar plots in B show the PC1 for individual mice and correspond to an expressed decrease for negative values and increased expression for positive values. The percentage of new cells, derived from an in vivo measure of 2H incorporation into newly synthesized DNA, is shown for islets and adipose tissue (C). Where significant obesity-dependent differences were observed, P-values are shown. Arrows are used to show influence of obesity. NS, not significant.
