Figure 1.
Ten-week-old BTBR ob mice are severely diabetic. (A) Schematic representation of experimental model depicting a gene expression network connecting key tissues in a mouse when examined over three primary axes: obesity, strain, and age. Clinical phenotypes are shown for five to seven animals for each of the eight groups of mice used for study. Plasma glucose (B), insulin (C), total number of islets harvested per pancreas (D), adiponectin (E), PAI-1 (F), and resistin (G) are plotted. Open (lean) and closed (ob/ob) circles represent individual mice. Horizontal bars show mean values for each group (±SD).
