Figure 7.
Predicted mechanism for unequal crossing-over leading to the WBS deletion. Heterozygosity for a large CNV in the region, such as the represented WBS-CNV1del, can facilitate the misalignment of chromosome 7 homologs in meiosis I and the unequal crossing-over (black X) between blocks Bc and Bm, leading to the most common 1.55-Mb WBS deletion. The normal allele is represented with continuous lines and arrows, while the chromosome carrying the CNV is represented by dotted lines and arrows.
