Panel construction for mapping in admixed populations via expected mutual information
Abstract
Mapping by admixture linkage disequilibrium (MALD) is an economical and powerful approach for the identification of genomic regions harboring disease susceptibility genes in recently admixed populations. We develop an information-theory-based measure, called expected mutual information (EMI), which computes the impact of a set of markers on the ability to infer ancestry at each chromosomal location. We then present a simple and effective algorithm for the selection of panels that strives to maximize the EMI score. Finally, we demonstrate via well-established simulation tools that our panels provide more power and accuracy for inferring disease gene loci via the MALD method in comparison to previous methods.
Footnotes
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↵4 Corresponding author.
↵4 E-mail sberco{at}cs.technion.ac.il; fax 972-4-8293900.
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Article published online before print. Article and publication date are at http://www.genome.org/cgi/doi/10.1101/gr.073148.107.
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- Received October 17, 2007.
- Accepted February 12, 2008.
- Copyright © 2008, Cold Spring Harbor Laboratory Press
