Figure 6.
Global maintenance of exonic splicing motifs (comparing human to macaque). Motif change is defined as the number of ESE or ESS hexamers in a human exon minus the number in its macaque ortholog. Splicing promotion for an exon is defined as the ESE number minus the ESS number for that exon. In the simulated sets, the same number and type of differences seen in human exons were placed randomly among synonymous sites of macaque exons, as described in the text. Similar results simulating macaque differences in human exons are shown in Supplemental Fig. S4.
