Segmental duplications and evolutionary plasticity at tumor chromosome break-prone regions

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Figure 7.
Figure 7.

Isochore surrounding of TBSDs. Average GC levels were assessed over 500-kb DNA stretches distal and proximal to each TBSD. The colored boxes show correspondence of these stretches to different class isochores (see at right). (Ovals) TBSD; (black circles) telomeres; (double-headed arrows) recent human branch-specific evolutionary inversions. In the case of chr 3, three successive inversions changed the orientation of TBSD regions. In the case of chr 7, one additional inversion changed the orientation of the chr7:97 region as shown by the green arrow.

This Article

  1. Genome Res. 18: 370-379

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