Segmental duplications and evolutionary plasticity at tumor chromosome break-prone regions

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Figure 4.
Figure 4.

Two-color FISH of TBR1 probes on orangutan chromosomes. BAC RP11-266L17 (red) identifies orangutan region, orthologous to unique human site telomeric to TBSD (see blue in Supplemental Fig. 7E). (A) Mixed BACs RP11-71K3 and RP11-1053M22 (green) identify TBSD orthologous sequences on two orangutan chromosomes, different from human chr 3 ortholog. (B) Mixed BACs, RP11-666K17 and RP11-139H7 (green), identify RBSD orthologous sequences as multiple signals on the short arms of acrocentric chromosomes. BAC RP11-266L17 signal (red) is not overlapping to green signal, showing that a chromosomal rearrangement occurred within the TBSD site during human–orangutan divergence.

This Article

  1. Published in Advance January 29, 2008, doi: 10.1101/gr.7010208 Genome Res. 18: 370-379

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