Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b

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Figure 3.
Figure 3.

Amplicons across the phox2b display significant functional overlap. The total interval assayed is depicted by color-coded rectangles: red (ZCS), green (ZNCS), purple (phox2b exons), and blue (phox2b introns). (a,b) Images corresponding to functional ZCS constructs. (a) 72-hpf zebrafish embryos with arrow marking ENS expression (ZCS −8.3 and ZCS −23.7). (b) Images indicating the range of hindbrain expression patterns driven by ZCS constructs. (c) Images indicating the range of hindbrain expression patterns driven by ZNCS constructs.

This Article

  1. Published in Advance December 10, 2007, doi: 10.1101/gr.6929408 Genome Res. 18: 252-260

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