Overlapping euchromatin/heterochromatin- associated marks are enriched in imprinted gene regions and predict allele-specific modification

Examples of double hits associated with known imprinted genes. The red and green tracks show log₂ ratios of IP/Input for DNAm and H3K4Me2, respectively. The orange blocks denote double hits and blue blocks denote CTCF binding sites. Genes are shown on the bottom in brown: blocks and lines represent exons and introns, respectively. Transcription direction is indicated by arrows. (A) MEST and MESTIT1: A triple hit (including CTCF) was found overlapping the alternative transcript MESTIT1, and a double hit was found at the MEST start site itself. (B) PEG10 and SGCE: A triple hit was found at the shared promoter of these two genes. (C) KCNQ1 and KCNQ1OT1: A triple hit was observed 800 bp upstream of KCNQ1OT1, with KCNQ1. (D) SNRPN and SNURF: A double hit was found at the point of overlap of these two genes at the promoter of SNURF.