Figure 1.
Most E2F1 binding regions do not contain a consensus E2F motif. Using E2F1 ChIP-chip data from two biologically independent cultures of MCF7 cells (Xu et al. 2007), we called peaks for each of the ∼24,100 1.5-kb promoter regions. We ranked the promoters by the enrichment values (E2F1 IP vs. Input) of the peaks and then binned the promoters into ranked sets of 100 (x-axis). The ratio of promoters in each bin that contain a consensus E2F site is indicated on the y-axis. For comparison, the approximate location of the bin containing the CCNA1 promoter, a well-characterized E2F target, is shown.
