Use of shotgun proteomics for the identification, confirmation, and correction of C. elegans gene annotations

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Figure 5.
Figure 5.

Correction of a misannotated coding sequence. The gene alh-3 (F36H1.6) contains six exons (pink) and encodes a dehydrogenase in C. elegans according to WormBase 150. We have identified two unique peptides (blue) between exons 2 and 3 that span the genomic region 11,022,575–11,025,702 on chromosome IV. Both peptides lie at least partially within an intron. This gene model has since been fixed in WS180.

This Article

  1. Published in Advance July 24, 2008, doi: 10.1101/gr.077644.108 Genome Res. 18: 1660-1669

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