A nuclear matrix attachment site in the 4q35 locus has an enhancer-blocking activity in vivo: Implications for the facio-scapulo-humeral dystrophy

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Figure 5.
Figure 5.

Loop domain organization and transcriptional control in the 4q35 region. (Top) In the presence of an intact D4Z4 array, the FR-MAR is attached to the nuclear matrix, protecting the genes in one chromatin loop from the enhancing activity of D4Z4 located in the next loop. (Bottom) The D4Z4 repeat array is reduced in size, delocalizing FR-MAR from the matrix, resulting in the FRG1/FRG2 genes being present in the same loop as and up-regulated by the remaining D4Z4 repeats.

This Article

  1. Published in Advance November 21, 2007, doi: 10.1101/gr.6620908 Genome Res. 18: 39-45

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