
Sequence diversity of the most and least conserved 7-mers as a function of the number of TFs in the genome. For each genome we ordered all 7-mers by their evidence for being under purifying selection and collected the most and least conserved unique 7-mers such that each 7-mer of both sets accounts for 5% of all sequence segments in the genome. The vertical axis shows the ratio between the number of most conserved and least conserved 7-mers in the corresponding set as a function of the total number of TFs in the genome (horizontal axis). Both axes are shown on logarithmic scale. The black line shows a linear fit.











