Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains

Click on image to view larger version.

Table 2.

Mitochondrial DNA haplotype grouping of 43 strains of rats

Click on table to view larger version.

Table 2.

We identified four haplotype groups by genotype analysis of 16 mitochondrial DNA polymorphisms in 43 rat strains including the SHR and BN progenitor strains. The specific variants present at each nucleotide site in the SHR and BN strains are listed in Tables 1 and Supplemental Table 1.

aHaplotype Group 1 consisted of 20 strains: ACI/Ztm, BC/CpbU, BDE/Han, BDIV/Ifz, BDIX/Han, BH/Ztm, BUF/Han, COP/OlaHsd, DA/Han, F344/Han, NAR/SaU, NEDH/K, PVG/OlaHsdCp, R/A, RHA/Kun, SDL/Ipvc, SPRD-Cu3/Han, SR/JrIpvc, SS/JrIpvc, WF/Han. Group 2 consisted of 17 strains: AS/Ztm, AVN/Orl, BBWB/Mol, BDII/Han, BS/Ztm, LE/Han, LEW/OlaHsd, LOU/C, MNS/Gro, MW/Hsd, OM/Han, SD/Rij, SDH/Ztu, WF/Gut, WIST/Nhg, WOK.1A/K, WOK/w/K. Group 3 consisted of four strains: SHR/Ola, OKA/Wsl, GC/Kun, WKY/M. Group 4 consisted of two strains: BN/Ola, DZB/Gro. The DZB/Gro strain was derived by a cross of BN rats with AO rats.

bNucleotides causing amino acid substitutions.

This Article

  1. Genome Res. 17: 1319-1326

Preprint Server