Somatic rearrangements in BACs. (A) Chromosome 17q21 amplicon in HCC1954 including ERBB2; (B) chimeric amplicon in HCC1954 including MYC; (C) chimeric amplicon in NCI-H2171 including MYC; (D) chromosome 2 amplicon in NCI-H1770 including MYCN. The color of the arrow identifies the chromosome, and the direction of the arrow indicates the orientation of DNA sequence relative to the reference genome (+ or − orientation); IVD, putative inverted duplications; black rectangles, DNA “insertions” that do not align to the reference human genome sequence with either flanking sequence. Figure parts are drawn to emphasize the types and complexity of rearrangements within the clone sequences and are therefore not drawn to scale.
