Domain-wide regulation of gene expression in the human genome

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Figure 5.
Figure 5.

Correlation between GFP expression and domain activity for various relative positions within and outside the domain. All clones with a GFP construct in a ridge or anti-ridge (n = 36) were aligned on the position of their GFP construct. For all clones, the border with the largest physical distance to the GFP integration site was determined (far border) and used to orient them alike. Using a window of 21 genes, the domain activity was determined at various relative positions within the domain at 25%, 50%, 75%, and 100% (i.e., the border) of the physical distance between the GFP construct and each border. The domain is represented by a gray box in between both borders. Using the same window size, correlation was calculated outside the domain at a distance of 11, 31, and 51 genes. Correlation is significant for all positions within the domain (P < 0.028), but not for any position on the border or outside the domain.

This Article

  1. Genome Res. 17: 1286-1295

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