Domain-wide regulation of gene expression in the human genome

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Figure 2.
Figure 2.

Expression of GFP constructs and genes in different chromosomal domains. (A) Average GFP expression of all clones with integrations in ridges (n = 22), intermediate domains (i.e., neither ridge nor anti-ridge; n = 54), or anti-ridges (n = 14). (B) Average expression (based on 133 pooled SAGE libraries) of all human genes embedded in ridges (n = 4250), intermediate domains (n = 13,226), or anti-ridges (n = 2906). (C) Average GFP expression of the clones harboring integration sites with the highest (n = 10) and lowest (n = 10) domain activities (defined as the median expression of the surrounding 49 genes in 133 pooled SAGE libraries). Error bars represent standard error of the mean.

This Article

  1. Genome Res. 17: 1286-1295

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