Cover image

Cover Regulation of gene expression by chromosomal domains. An artist impression of a cell nucleus with human chromosomes (blue DNA helices) illustrating how chromosomal domains modulate the expression of genes. Green viruses depict green fluorescent protein (GFP) gene introduction by lentivirus into human chromosomes. The virus in the foreground represents a poorly expressed GFP gene within an inactive domain (anti-ridge), whereas the bright fluorescent light emitted from the virus in the background (center left) represents the up-regulation of GFP expression via a GFP gene embedded in an active domain (ridge). (Cover illustration by Esteban Aravena and Hinco J. Gierman. [For details, see Gierman et al., pp. 1286–1295.])