
Phylogenetic tree of Mav (a), Mle (l) and the M. tuberculosis group (t). The common ancestor to t and l is designed as i. Two periods are considered in the branch of Mle: a first period as an active gene (g) and a second period as a pseudogene (ps). Parameters y and z are the numbers of nonsynonymous substitutions per nucleotide site in the Mle branch, in the event that the active gene had reached the present time or it had evolved as a pseudogene from i until the present, respectively. dNit is the number of nonsynonymous substitutions from the ancestor to Mtu.











