The core neuronal PDI network contains two specifier TF modules. (A) From a PDI network to a topological overlap network. (B) Topological overlap matrix for the interactors using the geometric formula and the resulting topological overlap network for interactor pairs with a topological coefficient ≥0.2. (Pink) Interactors in module 1 that connect to the promoter hubs Pdaf-3, Pcog-1, and Pnhr-79; (green) interactors in module 2 that bind the promoter hub Punc-30, in addition to Pceh-23, Pnhr-83, PT22H9.4, Pnhr-41, Pttx-1, Pdaf-19, Phlh-2, Pnhr-6, or Plin-32. (See Supplemental Fig. 5 for the modules obtained with the meet/min formula.) (C) PDI network corresponding to the interactors indicated in B. (Red) Paired homeodomain; (orange) other homeodomain, (R) reproduction; (B) response to stimulus (behavior). The average outgoing degree is indicated.
