A C. elegans core neuronal PDI network. (A) The core neuronal PDI network visualized using Cytoscape v2.3 (for a larger depiction, see Supplemental Fig. S4). (B) From PDIs to transcription regulatory interactions by data integration. (Top) Three autoregulatory PDIs confirmed proposed regulatory interactions. DAF-19 was proposed to regulate its own expression because the daf-19 promoter contains a predicted DAF-19 binding site (RFX box). (Middle) Two new PDIs may be involved in the determination of bilateral asymmetry in neurons. (Bottom) Two putative interologs/regulogs. Dotted lines with arrow (activation) or blunt arrow (repression), regulation; solid lines with dotted arrow, physical interaction.
