Transcription factor binding and modified histones in human bidirectional promoters

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 8.
Figure 8.

Mutagenesis of a 30-bp bidirectional fragment. Bases essential for promoter activity in each direction are underlined. Transversion mutations were introduced three bases at a time and shifted two bases for a total of 15 mutants. Mutation of a 12-bp region annihilates promoter activity in both directions. The consensus CCGGAARYR is recognized by the transcription factor GABPA. Asterisks (*) indicate position of transcription start sites.

This Article

  1. Genome Res. 17: 818-827

Preprint Server



Current Issue

  1. February 2026, 36 (2)
  1. Current Issue
  1. Alert me to new issues of Genome Research