Identification of an OCT4 and SRY regulatory module using integrated computational and experimental genomics approaches

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 7.
Figure 7.

OCT4, SRY, and KAP1 bind to a common set of target promoters. Using OCT4 and SRY ChIP-chip experiments from the same set of cross-linked Ntera2 cells, 880 of the SRY targets were classified as SRY+ and OCT4+ because of their presence in the top 2000 ranked promoters from both lists. To identify the SRY+ and OCT4− promoters, the top 2000 SRY targets were ranked according to their OCT4 enrichment values, and the bottom 389 promoters were chosen. Then, these two sets of promoters (SRY+ OCT4+ and SRY+ OCT4−) were compared to the top 1000 KAP1 targets.

This Article

  1. Genome Res. 17: 807-817

Preprint Server



Current Issue

  1. February 2026, 36 (2)
  1. Current Issue
  1. Alert me to new issues of Genome Research