Amy A. Baran; Karen A. Silverman; Joseph Zeskand; Revati Koratkar; Ashley Palmer; Kristen McCullen; Walter J. Curran; Tina Bocker Edmonston; Linda D. Siracusa; Arthur M. Buchberg

The modifier of Min 2 (Mom2) locus: Embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression

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Figure 5.

Polyps from B6 Apc^Min/+, Mom2^R/+ mice tend to be more advanced than polyps from B6 Apc^Min/+ mice. Microdissected polyps were stained with hematoxylin and eosin and photographed on a Nikon Eclipse E600 microscope at 100× magnification. (A,C,E,G,I) Isolated from B6 Apc^Min^/+ Mom2^+/+ mice as indicated. (B,D,F,H,J) Isolated from B6 Apc^Min^/+ Mom2^R^/+ mice as indicated. Size measurements revealed that adenomas in Apc^Min/+ Mom2^R/+ mice were threefold larger than the adenomas in Apc^Min/+ Mom2^+/+mice (P = 0.03) (data not shown).

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Published in Advance March 26, 2007, doi: 10.1101/gr.6089707 Genome Res. 2007. 17: 566-576

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The modifier of Min 2 (Mom2) locus: Embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression

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