Table 2.
Consensus motifs at splice sites show significant conservation
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Of 1985 introns observed in macroRNA transcripts, 1729 exhibit the canonical splice-site motif. Of these, 669 and 1322 align to orthologous human and rat sequence, respectively. The conservation of such aligning consensus splice sites is significantly higher than that of nearby intronic consensus motifs that show no evidence of splicing in the mouse (P = 9.5 × 10−5 and P = 2.0 × 10−4; χ2 test).
