Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates

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Figure 5.
Figure 5.

Two GRBs associated with genes encoding microRNAs; both also containing a myocyte enhancer factor gene. (Top) Human/zebrafish mirn9-1 occupies the same relative position in both genomes, flanked by rhbg and mef2d genes, and hosted within C1orf61 in human, also represented by an EST sequence in zebrafish (yellow). Insertion CLGY8 is expressed, at 24 hpf, in the dorsal telencephalon. (Lower track) Zebrafish mirn9-5 and human mirn9-2 are located near mef2c in a gene desert spanned by multiple HCNEs (green ovals). Insertion CLGY750 is ∼100 kb distal to mirn9-5 and, at this stage, has the same expression pattern as mirn9-1, in the dorsal telencephalon. For expression patterns of zgc:63626, mef2c, and rhbg, see Supplemental Figure S1.

This Article

  1. Genome Res. 17: 545-555

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