Inferring genome-wide functional linkages in E. coli by combining improved genome context methods: Comparison with high-throughput experimental data

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Figure 4.
Figure 4.

DicA subnetwork. dicA is known to be an essential gene in E. coli. Intriguingly, we observed that DicA has a degree of only 2. However, as is clear from the subgraph, deletion of DicA leads to disconnected islands in the subnetworks, thereby offering an explanation to its essentiality.

This Article

  1. Published in Advance March 5, 2007, doi: 10.1101/gr.5900607 Genome Res. 17: 527-535

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