Figure 1.
Effect of gene conservation score on the accuracy of protein–protein interaction predictions using phylogenetic profiles. (A) Profiles of the two genes in a pair are compared using the normalized bit scores. (B) Profiles of the two genes in a pair are compared using the presence (1) or absence (0) of the genes. Accuracy is defined as the average of sensitivity and specificity as described in Methods. It is clearly seen that the prediction accuracy is poorer at low and high conservation scores. See text for details.
