A palindrome-driven complex rearrangement of 22q11.2 and 8q24.1 elucidated using novel technologies

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Figure 6.
Figure 6.

Model for the two-step genesis of the complex rearrangement observed in the supernumerary der(22)t(8;22) proband’s father. A germline inversion of a 22q11.2 region flanked by breakpoints in LCRs A and D occurred before a t(8;22) translocation, the breakpoints of which are located at the center of palindromic sequences at the recurrent LCR-B site (open arrows) and an AT-rich locus of 8q24.13 (solid arrows).

This Article

  1. Published in Advance March 9, 2007, doi: 10.1101/gr.6130907 Genome Res. 17: 470-481

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