A palindrome-driven complex rearrangement of 22q11.2 and 8q24.1 elucidated using novel technologies

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Figure 3.
Figure 3.

The 8q24.1 breakpoint maps to a 29.543-kb region containing the RNF139 gene. (A) Schematic diagram depicting the location of BAC clone and PCR-generated FISH probes relative to the RNF139 gene. FISH was performed on metaphase spreads from the balanced t(8;22) carrier using fluorescently labeled BAC clones: RP11–495d4 (green) and RP11–532m24 (red) (B), RP11–158k1 (C), and PCR-generated probes labeled in red (D) and green (E).

This Article

  1. Published in Advance March 9, 2007, doi: 10.1101/gr.6130907 Genome Res. 17: 470-481

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