Molecular cloning of a translocation breakpoint hotspot in 22q11

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Figure 2.
Figure 2.

Molecular cloning and characterization of the PATRR22. (A) PCRad for four individuals. PCR products appearing as prominent bands did not contain the PATRR22. The DNA fraction indicated by the thick bracket contains the authentic PATRR22. Bands indicated by a thin bracket with an asterisk are derived from LCR22s with the standard structure. (B) Structure of the PATRR22. Hatched arrows indicate each unit of inverted repeats. Small arrows depict PCR primers. (C) Characteristics of the three translocation-related PATRRs. Arrows indicate each unit of inverted repeats of the PATRR. Black boxes indicate relatively non-AT-rich regions, while stippled boxes indicate the AT-rich regions flanking the PATRRs.

This Article

  1. Genome Res. 17: 461-469

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